Document Detail

Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine.
MedLine Citation:
PMID:  20093799     Owner:  NLM     Status:  MEDLINE    
Our aim was to investigate the effects of ageing on the vascular contractility of carotid and basilar arteries from guinea-pigs, in a model of total stenosis. Moreover, we attempted to identify whether total stenosis of the left common carotid (stenosed) in adult guinea-pigs, would affect the contractions of contralateral carotid (intact) and basilar arteries to different vasoconstrictors. With this purpose, the left carotid was occluded with a silk thread at a position close to its origin. Vascular reactivity experiments using standard muscle bath were performed 7, 15, 30, and 90 days after carotid occlusion. Reactivity of carotid and basilar arteries to endothelin-1, phenylephrine and KCl was reduced with ageing in naive guinea-pigs. The endothelin-1 and KCl-induced contractions were unaltered in arteries from SHAM-operated animals. Moreover, phenylephrine-induced contractions were reduced in both carotids from 7 days SHAM-operated guinea-pigs, when compared to naive group. Stenosis induced progressive reduction in the contraction induced by endothelin-1, phenylephrine and KCl in the stenosed carotid, when compared to their respective age-matched naive and SHAM groups. Interestingly, an increased contractile-response to vasoconstrictor agents in all the contralateral carotids was observed. Stenosis (30 and 90 days) also induced an increase in the contractions induced by endothelin-1 in the basilar artery. Conversely, phenylephrine and KCl-induced contractions were reduced in basilar arteries 7, 15, 30 and 90 days after stenosis. These results showed that stenosis in adult guinea-pigs induce alterations of vascular reactivity in arteries distant from the site of injury. Thus, in spite of the common use of contralateral carotid as control, it must be aware of the potential alteration induced by stenosis in the vascular motility of such vessels. Additionally, it was verified a relationship between the period of stenosis and the alterations in the vascular reactivity to these vasoconstrictors.
Claudia Roberta de Andrade; Fernando Morgan de A Corrêa; Ana Maria de Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi     Volume:  45     ISSN:  1884-8796     ISO Abbreviation:  J Smooth Muscle Res     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-25     Revised Date:  2011-04-19    
Medline Journal Info:
Nlm Unique ID:  9211664     Medline TA:  J Smooth Muscle Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  307-21     Citation Subset:  IM    
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
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MeSH Terms
Aging / physiology*
Basilar Artery / drug effects,  physiology
Carotid Arteries / drug effects,  physiology
Carotid Stenosis / physiopathology*
Dose-Response Relationship, Drug
Endothelin-1 / pharmacology*
Guinea Pigs
Phenylephrine / pharmacology*
Potassium Chloride / pharmacology
Vasoconstriction / drug effects*,  physiology
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Endothelin-1; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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