Document Detail


AGING AND SEQUENTIAL RESISTANCE EXERCISE BOUT EFFECTS ON HOUSEKEEPING GENE mRNA EXPRESSION IN HUMAN SKELETAL MUSCLE.
MedLine Citation:
PMID:  23085978     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: The purpose of this study was to investigate how age and one week of conventional resistance exercise affects commonly used housekeeping gene (HKG) mRNAs in skeletal muscle. Ten college-aged (18-25y) and ten older (60-76y) males completed three lower-body resistance exercise bouts on Monday, Wednesday, Friday and muscle samples were obtained prior to bout one (T1), 48 h following the first (T2) and second bouts (T3), and 24 h following the third bout (T4). Raw Ct values indicated that β-actin and cyclophilin were more highly expressed in older versus younger males (p < 0.01) at T1. When normalizing each HKG mRNA to the other four HKG mRNAs, CYC increased at T3 and glyceraldehyde 3-phosphate dehydrogenase decreased at T2 (p < 0.05) in younger males. This is one of the few studies to suggest that explicit HKG mRNAs should be used depending upon age group and resistance exercise intervention.
Authors:
Kyle L Sunderland; Michael D Roberts; Vincent J Dalbo; Chad M Kerksick
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-18
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  -     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Health and Exercise Science University of Oklahoma Norman, OK 73019-6081 2Department of Biomedical Science University of Missouri-Columbia Veterinary Medicine Building Columbia, MO 65211 3Institute for Health and Social Science Research School of Medicine and Applied Sciences Faculty of Sciences, Engineering and Health Central Queensland University Rockhampton, QLD 4702, Australia 4Health, Exercise and Sports Sciences Department University of New Mexico Albuquerque, NM 87131.
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