| Aging per se increases the susceptibility to free fatty acid-induced insulin resistance. | |
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MedLine Citation:
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PMID: 20504893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevations in systemic free fatty acids (FFA) contribute to insulin resistance. To determine the effects of an acute elevation in FFA on insulin action with aging, we infused saline or intralipid (IL) during a hyperinsulinemic-euglycemic clamp in three groups of rats: young ad libitum-fed (YAL), old ad libitum-fed (OAL), and old on lifelong calorie restriction (OCR). The OCR group was included to distinguish between aging per se and age-related changes in body fat distribution. IL induced marked insulin resistance in both YAL and OCR, but the onset of insulin resistance was approximately two to three times more rapid in OCR as compared with YAL. In response to IL infusion, plasminogen-activating inhibitor-1 (PAI-1) expression was increased in subcutaneous fat from OAL animals. In visceral fat, a marked increase in PAI-1 and interleukin-6 expression was observed in OAL and OCR rats, but not YAL, in response to IL treatment. Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging. |
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Authors:
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Francine H Einstein; Derek M Huffman; Sigal Fishman; Elina Jerschow; Hye J Heo; Gil Atzmon; Clyde Schechter; Nir Barzilai; Radhika H Muzumdar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 65 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-08-04 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 800-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics & Gynecology and Women's Health at Montefiore Medical Center, Bronx, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Animals Caloric Restriction Fat Emulsions, Intravenous / toxicity Fatty Acids, Nonesterified / toxicity* Glucose / metabolism Inflammation / metabolism Insulin Resistance* Interleukin-6 / genetics Macrophages / physiology Plasminogen Activator Inhibitor 1 / genetics Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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AG18381/AG/NIA NIH HHS; AG21654/AG/NIA NIH HHS; DK20541/DK/NIDDK NIH HHS; K08 AG027462/AG/NIA NIH HHS; T32AG23475/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Interleukin-6; 0/Plasminogen Activator Inhibitor 1; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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