Document Detail

Aging and oxidatively damaged nuclear DNA in animal organs.
MedLine Citation:
PMID:  20149865     Owner:  NLM     Status:  MEDLINE    
Oxidative stress is considered to contribute to aging and is associated with the generation of oxidatively damaged DNA, including 8-oxo-7,8-dihydroguanine. We have identified 69 studies that have measured the level of oxidatively damaged DNA in organs of animals at various ages. In general, organs with limited cell proliferation, i.e., liver, kidney, brain, heart, pancreas, and muscle, tended to show accumulation of DNA damage with age, whereas organs with highly proliferating cells, such as intestine, spleen, and testis, showed more equivocal or no effect of age. A restricted analysis of studies reporting a baseline level of damaged DNA that was fewer than 5 lesions/10(6) dG showed that 21 of 29 studies reported age-associated accumulation of DNA damage. The standardized mean difference in oxidatively damaged DNA between the oldest and the youngest age groups was 1.49 (95% CI 1.03-1.95). There was no difference between age span, number of tested organs, statistical power, sex, strain, or breeding between the studies showing positive and null effects. Citation and publication bias seems to be a problem in the overall dataset, whereas it is less pronounced in the restricted dataset. There is compelling evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation.
Peter Møller; Mille Løhr; Janne K Folkmann; Lone Mikkelsen; Steffen Loft
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-10
Journal Detail:
Title:  Free radical biology & medicine     Volume:  48     ISSN:  1873-4596     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1275-85     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Section of Environmental Health, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark.
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MeSH Terms
Animal Structures / metabolism*,  pathology
Cell Nucleus / genetics,  metabolism
Cell Proliferation
DNA Damage*
Databases as Topic
Guanine / analogs & derivatives,  metabolism
Oxidative Stress*
Publication Bias
Reg. No./Substance:
5614-64-2/8-hydroxyguanine; 73-40-5/Guanine

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