Document Detail


Aging mechanisms in arthritic disease.
MedLine Citation:
PMID:  23200066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arthritic disease is one of the most common age-related pathologies worldwide. The erosion of cartilaginous tissues from articular surfaces within the joint and the failure to efficiently repair and regenerate this region with age lead to debilitating joint destruction, severe pain, and a crippling loss of function. In addition to the accumulative damage brought about by years of mechanical forces acting upon this region of tissue, there are also defects in underlying biological mechanisms which predispose the older population to excessive joint erosion. This occurs as aberrations in normal chondrocyte biology lead to a reduction in crucial matrix proteins and inhibitory molecules, and elevated production of destructive enzymes. The end result is an accelerated loss of articular cartilage and increased erosion of the joint. As a significant global link exists between aging and the onset of arthritis, this review will consider whether factors known to affect lifespan may also play a role in arthritic disease.
Authors:
Pradeep K Sacitharan; Sarah J B Snelling; James R Edwards
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Discovery medicine     Volume:  14     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / pathology*,  physiology*
Arthritis / metabolism*,  pathology,  physiopathology
Arthritis, Rheumatoid / metabolism,  pathology,  physiopathology
Cartilage, Articular / metabolism
Chondrocytes / cytology
Humans
Osteoarthritis / metabolism,  pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
19222//Arthritis Research UK; 20087//Arthritis Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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