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Aging-like circadian disturbances in folate-deficient mice.
MedLine Citation:
PMID:  23273571     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The elderly population shows various circadian disturbances, including dampened amplitude of rhythmicity and decreased responsiveness to light. The common poor folate status in the elderly might account for these aging-related circadian disturbances. To test this hypothesis, we investigated whether folate deficiency in mice affects circadian oscillations of the master clock in the suprachiasmatic nuclei, and the shifting responses to light. Mice fed a diet without folate for 6 weeks displayed markedly reduced (4.5-fold) erythrocyte folate concentration and increased (2.3-fold) homocysteinemia compared with control mice. Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection. In conclusion, folate deficiency and consecutive hyperhomocysteinemia led to dampened PER2 and vasopressin oscillations in the master clock and reduced responsiveness to photic resetting, which constitute hallmarks of aging effects on circadian rhythmicity.
Authors:
Etienne Challet; Stéphanie Dumont; Madah K M Mehdi; Caroline Allemann; Tiffanie Bousser; Sylviane Gourmelen; Dominique Sage-Ciocca; David Hicks; Paul Pévet; Bruno Claustrat
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-25
Journal Detail:
Title:  Neurobiology of aging     Volume:  -     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, CNRS UPR3212 associated with University of Strasbourg, Strasbourg, France. Electronic address: challet@inci-cnrs.unistra.fr.
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