| Aging and the intestine. | |
| | |
MedLine Citation:
|
PMID: 17171784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Over the lifetime of the animal, there are many changes in the function of the body's organ systems. In the gastrointestinal tract there is a general modest decline in the function of the esophagus, stomach, colon, pancreas and liver. In the small intestine, there may be subtle alterations in the intestinal morphology, as well as a decline in the uptake of fatty acids and sugars. The malabsorption may be partially reversed by aging glucagon-like peptide 2 (GLP2) or dexamethasone. Modifications in the type of lipids in the diet will influence the intestinal absorption of nutrients: for example, in mature rats a diet enriched with saturated as compared with polysaturated fatty acids will enhance lipid and sugar uptake, whereas in older animals the opposite effect is observed. Thus, the results of studies of the intestinal adaptation performed in mature rats does not necessarily apply in older animals. The age-associated malabsorption of nutrients that occurs with aging may be one of the several factors which contribute to the malnutrition that occurs with aging. |
| | |
Authors:
|
Laurie Drozdowski; Alan B R Thomson |
Related Documents
:
|
9237964 - Olestra ingestion and dietary fat absorption in humans. 21279554 - Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. 9231394 - Is diet shifting facilitated by modulation of intestinal nutrient uptake? test of an ad... 16041474 - Ontogenetic development of the gastrointestinal microbiota in the marine herbivorous fi... 9846584 - Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neurope... 7719384 - Racial difference in body core temperature between pima indian and caucasian men. |
Publication Detail:
|
Type: Editorial; Review |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-12-15 Completed Date: 2007-02-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 7578-84 Citation Subset: IM |
Affiliation:
|
Nutrition and Metabolism Group, University of Alberta, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aging / physiology* Animals Humans Intestinal Absorption / physiology* Intestines / physiology* Malnutrition / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis.
Next Document: Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor ...