| Aging of the innate immune system. | |
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MedLine Citation:
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PMID: 20667703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like Receptors. However, aging is also characterized by a constitutive pro-inflammatory environment (inflamm-aging) with persistent low-grade innate immune activation that may augment tissue damage caused by infections in elderly individuals. Thus, immunosenescence in the innate immune system appears to reflect dysregulation, rather than exclusively impaired function. |
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Authors:
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Albert C Shaw; Samit Joshi; Hannah Greenwood; Alexander Panda; Janet M Lord |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in immunology Volume: 22 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 507-13 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ltd. |
Affiliation:
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Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, 300 Cedar St. Box 208022, New Haven, CT 06520, USA. albert.shaw@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging
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immunology* Humans Immune System / physiology* Immunity, Innate* |
| Grant Support | |
ID/Acronym/Agency:
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AG019134/AG/NIA NIH HHS; N0150031//PHS HHS; //Biotechnology and Biological Sciences Research Council |
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