| Aging and immortality in a cell proliferation model. | |
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MedLine Citation:
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PMID: 17631317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigate a model of cell division in which the length of telomeres within a cell regulates its proliferative potential. At each division, telomeres undergo a systematic length decrease as well as a superimposed fluctuation due to exchange of telomere DNA between the two daughter cells. A cell becomes senescent when one or more of its telomeres become shorter than a critical length. We map this telomere dynamics onto a biased branching-diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. Using first-passage ideas, we find a phase transition between finite lifetime and immortality (infinite proliferation) of the cell population as a function of the influence of telomere shortening, fluctuations, and cell division. |
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Authors:
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T Antal; K B Blagoev; S A Trugman; S Redner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-06-12 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 248 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-11 Completed Date: 2007-12-12 Revised Date: 2011-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 411-7 Citation Subset: IM |
Affiliation:
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Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging
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genetics* Cell Death / genetics Cell Division / genetics* Cell Survival / genetics DNA / genetics DNA Replication / genetics Humans Mathematics Models, Genetic Telomere / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM078986-01/GM/NIGMS NIH HHS; R01GM078986/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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