| Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions. | |
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MedLine Citation:
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PMID: 16234900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A classic hallmark of chronic heart failure (CHF) is exercise intolerance; however, the extent of exercise limitation is not correlated with the degree of left ventricular dysfunction. Over the past 2 decades it has become more and more evident that peripheral factors, such as skeletal muscle dysfunction, ventilatory abnormalities, and endothelial dysfunction, contribute the greater part to the limitation of exercise capacity. The molecular and pathophysiological changes observed in these organ systems are not always specific to the underlying CHF but rather represent a common pathway that is activated in several chronic disease processes, including severe chronic obstructive pulmonary disease, cancer, and in the normal aging process. A major contributing factor for skeletal muscle catabolism (i.e. elevated cytokine expression in the skeletal muscle) can be found in both normal healthy aging and in heart failure patients. It is reasonable to assume that the overlap of aging and CHF-associated changes in the skeletal muscle partially explains the disabling consequences of the CHF syndrome among elderly patients (nearly 80% of all patients hospitalized for CHF are >65 years old). Peripheral alterations in CHF are often not adequately treated in routine clinical care since standard pharmacological therapy is still focused on the cardiac function and neurohormonal alteration. Exercise training is a guideline-oriented adjuvant therapy with well-documented beneficial effects on exercise tolerance, skeletal muscle function, endothelial function, and respiration. In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored. |
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Authors:
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Stephan Gielen; Volker Adams; Josef Niebauer; Gerhard Schuler; Rainer Hambrecht |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Heart failure monitor Volume: 4 ISSN: 1470-8590 ISO Abbreviation: Heart Fail Monit Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-19 Completed Date: 2006-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101140283 Medline TA: Heart Fail Monit Country: England |
Other Details:
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Languages: eng Pagination: 130-6 Citation Subset: IM |
Affiliation:
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Universität Leipzig, Herzzentrum, Klinik für Innere Medizin/Kardiologie, Leipzig, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology* Disease Progression Exercise Therapy / methods Exercise Tolerance / physiology* Heart Failure / physiopathology*, rehabilitation Humans Prognosis Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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