| Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta). | |
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MedLine Citation:
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PMID: 7782913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Food restriction increases life span, reduces aging rate and affects a wide variety of biological functions. In rats, food restriction delays bone growth and reduces bone density and mineral content. We report the effects of aging and long-term (> 6.0 y) food restriction on several indices of bone growth and metabolism in rhesus monkeys (Macaca mulatta). Food allotments for controls approximated free access consumption, whereas food-restricted monkeys received 30% less food on a body weight basis. Cross-sectional and longitudinal age effects on serum alkaline phosphatase paralleled those reported for humans. Food restriction induced a significant delay in the developmental decline (to adult levels) in total alkaline phosphatase and significantly suppressed serum interleukin 6 concentrations, particularly in younger monkeys. Also, food restriction slowed skeletal growth, as reflected by shorter crown-rump length, and significantly reduced total body bone mineral content, but not bone mineral density, measured by dual energy X-ray absorptiometry. Analyses of serum parathyroid hormone, calcium, phosphate and osteocalcin concentrations suggested that the effects on skeletal growth were not related to alterations in calcium and phosphate homeostasis or a primary defect in bone formation. These findings suggest that long-term food restriction delays skeletal development in male rhesus monkeys while allowing the development of a reduced but otherwise normal skeleton. |
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Authors:
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M A Lane; A Z Reznick; E M Tilmont; A Lanir; S S Ball; V Read; D K Ingram; R G Cutler; G S Roth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 125 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-18 Completed Date: 1995-07-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1600-10 Citation Subset: IM; S |
Affiliation:
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Molecular Physiology and Genetics Section, Nathan Shock Laboratories, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Alkaline Phosphatase / analysis, blood Animals Bone Density / physiology Bone Development / physiology* Bone and Bones / enzymology, metabolism*, physiology Calcium / blood Food Deprivation / physiology* Homeostasis / physiology Interleukin-6 / blood Liver / enzymology Macaca mulatta / metabolism*, physiology Male Osteocalcin / blood Parathyroid Hormone / blood Phosphates / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Parathyroid Hormone; 0/Phosphates; 104982-03-8/Osteocalcin; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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