Document Detail

Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).
MedLine Citation:
PMID:  7782913     Owner:  NLM     Status:  MEDLINE    
Food restriction increases life span, reduces aging rate and affects a wide variety of biological functions. In rats, food restriction delays bone growth and reduces bone density and mineral content. We report the effects of aging and long-term (> 6.0 y) food restriction on several indices of bone growth and metabolism in rhesus monkeys (Macaca mulatta). Food allotments for controls approximated free access consumption, whereas food-restricted monkeys received 30% less food on a body weight basis. Cross-sectional and longitudinal age effects on serum alkaline phosphatase paralleled those reported for humans. Food restriction induced a significant delay in the developmental decline (to adult levels) in total alkaline phosphatase and significantly suppressed serum interleukin 6 concentrations, particularly in younger monkeys. Also, food restriction slowed skeletal growth, as reflected by shorter crown-rump length, and significantly reduced total body bone mineral content, but not bone mineral density, measured by dual energy X-ray absorptiometry. Analyses of serum parathyroid hormone, calcium, phosphate and osteocalcin concentrations suggested that the effects on skeletal growth were not related to alterations in calcium and phosphate homeostasis or a primary defect in bone formation. These findings suggest that long-term food restriction delays skeletal development in male rhesus monkeys while allowing the development of a reduced but otherwise normal skeleton.
M A Lane; A Z Reznick; E M Tilmont; A Lanir; S S Ball; V Read; D K Ingram; R G Cutler; G S Roth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  125     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-18     Completed Date:  1995-07-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1600-10     Citation Subset:  IM; S    
Molecular Physiology and Genetics Section, Nathan Shock Laboratories, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
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MeSH Terms
Aging / physiology*
Alkaline Phosphatase / analysis,  blood
Bone Density / physiology
Bone Development / physiology*
Bone and Bones / enzymology,  metabolism*,  physiology
Calcium / blood
Food Deprivation / physiology*
Homeostasis / physiology
Interleukin-6 / blood
Liver / enzymology
Macaca mulatta / metabolism*,  physiology
Osteocalcin / blood
Parathyroid Hormone / blood
Phosphates / blood
Time Factors
Reg. No./Substance:
0/Interleukin-6; 0/Parathyroid Hormone; 0/Phosphates; 104982-03-8/Osteocalcin; 7440-70-2/Calcium; EC Phosphatase

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