Document Detail


Aging, exercise, and cardioprotection.
MedLine Citation:
PMID:  15247066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial ischemia-reperfusion (I-R) injury is a major contributor to the morbidity and mortality associated with coronary artery disease. The incidence of I-R events is greatest in older persons, and studies also indicate that the magnitude of myocardial I-R injury is greater in senescent individuals compared to younger adults. Regular exercise has been confirmed as a pragmatic countermeasure to protect against I-R-induced cardiac injury. Specifically, endurance exercise has been proven to provide cardioprotection against an I-R insult in both young and old animals. Proposed mechanisms to explain the cardioprotective effect of exercise include the induction of myocardial heat shock proteins (HSPs), improved cardiac antioxidant capacity, and/or elevation of other cardioprotective proteins. Of these potential mechanisms, evidence indicates that elevated myocardial levels of heat shock proteins or antioxidants can provide myocardial protection against I-R injury. At present, which of these protective mechanisms is essential for exercise-induced cardioprotection remains unclear. Understanding the molecular basis for exercise-induced cardioprotection is important in developing exercise paradigms to protect the heart during an I-R insult.
Authors:
Scott K Powers; John Quindry; Karyn Hamilton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1019     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-12     Completed Date:  2004-08-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-70     Citation Subset:  IM    
Affiliation:
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA. spowers@hhp.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Antioxidants / pharmacology
Exercise*
Heart / physiology*
Heat-Shock Proteins / metabolism
Humans
Male
Myocardium / pathology*
Oxidative Stress
Physical Conditioning, Animal*
Protein Isoforms
Rats
Reperfusion Injury*
Superoxide Dismutase / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
R01 HL067855/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Heat-Shock Proteins; 0/Protein Isoforms; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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