| Aging, autonomic function, and the perception of angina. | |
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MedLine Citation:
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PMID: 1854569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of age and autonomic function on the perception of angina. DESIGN: Prospective evaluation of the relations between anginal perceptual threshold, autonomic function, and systolic blood pressure in patients with symptomatic coronary artery disease. Statistical analysis was by non-parametric techniques. SETTING: Cardiology departments of a district general hospital and a post-graduate teaching centre. SUBJECTS: 82 non-diabetic men with typical exertional angina and coronary artery disease confirmed by arteriography (n = 64) or a history of Q wave infarction (n = 18). MAIN OUTCOME MEASURES: Age, anginal perceptual threshold, autonomic function, and blood pressure. Anginal perceptual threshold was defined as the time from onset of 0.1 mV ST depression to the onset of angina during treadmill stress testing. Autonomic function was measured as the ratio of peak heart rate during the Valsalva manoeuvre to the minimum rate after release. RESULTS: Anginal perceptual threshold showed a weak but significant correlation with age, with older patients tending to have a longer interval between the onset of ST depression and the onset of angina. Comparison of patients in the upper and lower quartile age ranges showed a difference of 50 seconds between median threshold measurements. Blood pressure and heart rate responses to the Valsalva manoeuvre also correlated with age, but neither variable correlated with the anginal perceptual threshold. CONCLUSIONS: In non-diabetic men with coronary artery disease the perception of angina tends to deteriorate with advancing age. The mechanism is unclear but is not attributable solely to alterations in blood pressure or autonomic function. |
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Authors:
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V Umachandran; K Ranjadayalan; G Ambepityia; B Marchant; P G Kopelman; A D Timmis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British heart journal Volume: 66 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-08-27 Completed Date: 1991-08-27 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: AIM; IM |
Affiliation:
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Diabetic Unit, Newham General Hospital, London. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Angina Pectoris / physiopathology* Autonomic Nervous System / physiopathology* Coronary Disease / physiopathology Exercise Test Humans Male Middle Aged Perception / physiology* Prospective Studies Time Factors |
| Comments/Corrections | |
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