Document Detail

Aging-associated pancreatic exocrine insufficiency in the unanesthetized rat.
MedLine Citation:
PMID:  6207078     Owner:  NLM     Status:  MEDLINE    
Observations in individuals have suggested that pancreatic functions may be diminished with aging. In order to explore this possibility, we measured pancreatic fluid, protein and amylase output as a function of aging in the rat. Surgical preparations of the rats included external drainage of pancreatic secretions without obstructing normal bile flow and complete diversion of gastric acid out of the duodenum to prevent endogenous secretin release. Pancreatic secretions were collected in the basal state in unanesthetized animals 24 h after surgery. Protein and amylase output were highest at 3 months of age and decreased to less than 20% of maximal values by 27 months of age. For example, amylase output decreased from 4,354 to 105 U/h/kg and protein output fell from 33.5 to 1.7 mg/h/kg between 3 and 27 months of age. Our findings indicate that aging in the rat is associated with diminished pancreatic exocrine functions. Further careful assessment of pancreatic functions in aging individuals is advisable.
D Hollander; V D Dadufalza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gerontology     Volume:  30     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  218-22     Citation Subset:  IM    
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MeSH Terms
Amylases / analysis
Exocrine Pancreatic Insufficiency / enzymology,  physiopathology*
Pancreas / enzymology*
Proteins / analysis
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Proteins; EC 3.2.1.-/Amylases

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