| Aging, antagonistic pleiotropy and fibrotic disease. | |
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MedLine Citation:
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PMID: 20595011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue fibrosis is most often referred to in its pathological context and is a major cause of progressive organ failure and death. Here, we consider fibrosis as an evolutionarily conserved, adaptive tissue response to injury. The role of NADPH oxidase 4 (Nox4) as a novel pro-fibrogenic mediator is highlighted. The concept that Nox4 may function as an antagonistically pleiotropic gene in age-associated fibrotic disorders is discussed. |
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Authors:
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Victor J Thannickal |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-04 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-01 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1398-400 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, THT 422, Birmingham, AL 35294-0006, United States. vjthan@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics,
physiology* Animals Fibroblasts / metabolism, pathology, physiology Fibrosis / genetics, metabolism, physiopathology* Humans NADPH Oxidase / genetics, metabolism Reactive Oxygen Species / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-67967/HL/NHLBI NIH HHS; R01 HL-94230/HL/NHLBI NIH HHS; R01 HL067967-09/HL/NHLBI NIH HHS; R01 HL094230-01A1/HL/NHLBI NIH HHS; R01 HL094230-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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