Document Detail


Aging of animals produced by somatic cell nuclear transfer.
MedLine Citation:
PMID:  12559401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cloning by somatic cell nuclear transfer (NT) has been used to successfully generate viable mammalian embryos in many species. Despite the successful production of cloned animals, NT remains an inefficient technique at best. High rates of developmental failure and abnormalities are associated with NT-derived animals. Issues such as cell cycle regulation, epigenetic modification and oocyte activation have been examined in order to ultimately find ways to improve the efficiency of somatic cell NT. In reviewing the available literature regarding the generation of various mammalian species by using somatic cell NT, it becomes apparent that there are not only differences in the protocols used to generate such animals, but significant differences in the phenotypes of resultant animal clones as well. In this review we discuss the current findings about how aging and senescence are affected by somatic cell NT in mammals.
Authors:
Birgit Kühholzer-Cabot; Gottfried Brem
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experimental gerontology     Volume:  37     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-29     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1317-23     Citation Subset:  IM    
Affiliation:
Agrobiogen GmbH, Hilgertshausen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics*
Animals
Cattle
Cell Aging / genetics
Cloning, Organism / methods*
Mice
Nuclear Transfer Techniques
Sheep
Telomerase / metabolism
Telomere / physiology
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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