| Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake. | |
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MedLine Citation:
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PMID: 6619125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The molecular basis of the cognitive changes that accompany aging is unknown. Since several lines of evidence suggest that senescence may alter calcium homeostasis, 45calcium uptake was determined in brain synaptosomes from aged rats. In low potassium (5 mM KCl) media, aging altered calcium influx: 104.2% (3 months), 100.0% (6 months), 76.7% (15 months), or 58.6% (27 months). In 31 mM KCl media, uptake declined with age from 106.6% (3 months) to 100.0% (6 months), 67.8% (15 months), or 45.8% (27 months). 3,4-Diaminopyridine elevated the potassium-stimulated calcium influx 2.3% (3 months), 10.2% (6 months), 31.8% (15 months), or 78.8% (27 months) when they are compared to non-drug-treated synaptosomes of the same age. The calcium that binds superficially to the plasma membrane changed as the age increased from 3 months (105.4%) to 6 months (100.0%), 15 months (116.1%), or 27 months (141.4%). 3,4-Diaminopyridine reduced this binding at 15 or 27 months to 109.3 or 121.4%, when compared to the 6 month old rats respectively. The decline in synaptosomal calcium uptake may alter neuronal metabolism which leads to the reduction in mental function that accompanies aging. |
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Authors:
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C Peterson; G E Gibson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 258 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 11482-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminopyridine*
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analogs & derivatives* Aging Aminopyridines / pharmacology* Animals Biological Transport, Active / drug effects Brain / growth & development*, metabolism Calcium / metabolism* Kinetics Potassium / pharmacology Rats Rats, Inbred F344 Synaptosomes / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Aminopyridines; 461-88-1/2,4-diaminopyridine; 504-24-5/4-Aminopyridine; 7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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