Document Detail

Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake.
MedLine Citation:
PMID:  6619125     Owner:  NLM     Status:  MEDLINE    
The molecular basis of the cognitive changes that accompany aging is unknown. Since several lines of evidence suggest that senescence may alter calcium homeostasis, 45calcium uptake was determined in brain synaptosomes from aged rats. In low potassium (5 mM KCl) media, aging altered calcium influx: 104.2% (3 months), 100.0% (6 months), 76.7% (15 months), or 58.6% (27 months). In 31 mM KCl media, uptake declined with age from 106.6% (3 months) to 100.0% (6 months), 67.8% (15 months), or 45.8% (27 months). 3,4-Diaminopyridine elevated the potassium-stimulated calcium influx 2.3% (3 months), 10.2% (6 months), 31.8% (15 months), or 78.8% (27 months) when they are compared to non-drug-treated synaptosomes of the same age. The calcium that binds superficially to the plasma membrane changed as the age increased from 3 months (105.4%) to 6 months (100.0%), 15 months (116.1%), or 27 months (141.4%). 3,4-Diaminopyridine reduced this binding at 15 or 27 months to 109.3 or 121.4%, when compared to the 6 month old rats respectively. The decline in synaptosomal calcium uptake may alter neuronal metabolism which leads to the reduction in mental function that accompanies aging.
C Peterson; G E Gibson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  258     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11482-6     Citation Subset:  IM    
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MeSH Terms
4-Aminopyridine* / analogs & derivatives*
Aminopyridines / pharmacology*
Biological Transport, Active / drug effects
Brain / growth & development*,  metabolism
Calcium / metabolism*
Potassium / pharmacology
Rats, Inbred F344
Synaptosomes / drug effects,  metabolism*
Reg. No./Substance:
0/Aminopyridines; 461-88-1/2,4-diaminopyridine; 504-24-5/4-Aminopyridine; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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