Document Detail

Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.
MedLine Citation:
PMID:  7831179     Owner:  NLM     Status:  MEDLINE    
There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure. It is generally thought that doses below 500-550 mg/m2 are safe but, when objective measures of cardiac function are used, it becomes apparent that degrees of cardiac failure occur at doses below this. We present here the case histories of two patients who developed very severe cardiac failure at cumulative doses well below 500 mg/m2 but who survived their initial cardiac illness due to aggressive intervention. In one case, the patient was successfully treated by orthotopic cardiac transplantation.
S Sriskandan; M E O'Brien; I E Smith; P Collins; M E Gore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  70     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-61     Citation Subset:  IM    
Department of Medicine, Royal Marsden Hospital, London, UK.
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MeSH Terms
Cardiomyopathy, Dilated / chemically induced*,  therapy*
Dose-Response Relationship, Drug
Doxorubicin / administration & dosage,  adverse effects*
Drug Administration Schedule
Heart Transplantation
Lymphoma, B-Cell / drug therapy
Middle Aged
Rhabdomyosarcoma, Embryonal / drug therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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