| Aggressive lipid lowering treatment in coronary atherosclerosis. | |
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MedLine Citation:
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PMID: 9369038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduction of cholesterol by potent drugs in clinically symptomatic or asymptomatic patients with elevated cholesterol levels will substantially decrease the risk of coronary events. In selected cases more aggressive treatment of hyperlipidemia is necessary, such as in patients, homozygous for familial hypercholesterolemia, or subjects with severe coronary artery disease who are refractory to diet and drugs. LDL-apheresis, by which atherogenic lipoprotein particles are removed from the blood extracorporeally, is a therapeutic option in these cases. In this report a study is summarized, in which the effect of intervention with LDL-apheresis plus simvastatin was compared with conventional drug treatment alone in a group of patients with severe coronary artery disease with respect to changes in coronary atherosclerotic lesions and their functional impact. |
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Authors:
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A F Stalenhoef; A A Kroon; W R Aengevaeren |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiologia (Rome, Italy) Volume: 42 ISSN: 0393-1978 ISO Abbreviation: Cardiologia Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-22 Completed Date: 1997-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8506637 Medline TA: Cardiologia Country: ITALY |
Other Details:
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Languages: eng Pagination: 935-40 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Cardiology, University Hospital Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Apolipoproteins B / blood Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Angiography Coronary Circulation Coronary Disease / blood, physiopathology, therapy* Humans Hyperlipoproteinemia Type II / blood, physiopathology, therapy* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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