Document Detail


Aggressive hepatocellular carcinoma complicating pregnancy after autologous bone marrow transplantation for non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  11850714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the Asia-Pacific region, autologous and allogeneic bone marrow transplantation (BMT) in patients infected with the hepatitis B virus (HBV) may be complicated by fatal hepatic failure due to viral reactivation. Survivors may suffer from accelerated hepatitis and cirrhosis. We report the first case of hepatocellular carcinoma (HCC) after autologous BMT for mediastinal B cell lymphoma. The tumor developed rampantly during a planned pregnancy 5 years after BMT. Less than 40 cases of HCC complicating pregnancy have been reported, and outcome is invariably poor. Immunosuppression and HBV reactivation after autologous BMT, as well as immune tolerance and hormonal changes associated with pregnancy may contribute to the rapid tumor growth. Biochemical and radiological surveillance for HCC should be strengthened in HBV carriers after BMT, especially in patients with the histology of chronic liver disease, or biochemical/ virological evidence of increased HBV activity.
Authors:
W Y Au; A K W Lie; R Liang; C L Liu; T W Shek; G K Lau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  29     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2003-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Queen Mary Hospital, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow Transplantation / adverse effects*
Carcinoma, Hepatocellular / etiology*,  virology
Female
Hepatitis B virus / growth & development
Humans
Immunosuppression / adverse effects
Liver Neoplasms / etiology*,  virology
Lymphoma, B-Cell / therapy*
Mediastinal Neoplasms / therapy
Neoplasms, Second Primary / etiology*,  virology
Pregnancy
Pregnancy Complications, Neoplastic / etiology*,  virology
Transplantation, Autologous
Virus Activation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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