| Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead. | |
| | |
MedLine Citation:
|
PMID: 9811288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To report a case of a 3-year-old child with an extraordinarily massive lead concentration, 26.4 micromol/L (550 microg/dL), following environmental exposure to lead paint in the home. LITERATURE REVIEW: The relevant literature concerning the treatment of lead encephalopathy was reviewed during the treatment of this child and preparation of the manuscript. To our knowledge, the landmark article written by Julian Chisolm in 1968 is the only recent article that reported similarly high levels of lead concentration. This case, however, is the first in which 3 chelating agents were used for the treatment of lead encephalopathy. We also reviewed the literature on the use of whole bowel irrigation in heavy metal intoxications. CONCLUSIONS: In this case, aggressive gut decontamination with whole bowel irrigation and triple chelation therapy with British anti-Lewisite, EDTA, and oral succimer was well tolerated and seemed effective for rapidly deleading the child. The extent to which her lead concentration increased while being treated with oral succimer alone necessitated further chelation with EDTA. Further evaluation is necessary to determine if triple chelation therapy is an appropriate method for severe lead intoxication, and if the use of whole bowel irrigation should be considered in heavy metal intoxication. |
| | |
Authors:
|
R A Gordon; G Roberts; Z Amin; R H Williams; F P Paloucek |
Related Documents
:
|
10658538 - Clinical lead poisoning in england: an analysis of routine sources of data. 22260458 - Airway management of recovered pediatric patients with severe head and neck burns: a re... 20587768 - Rhabdomyolysis after lsd ingestion. 21446338 - A case of primary ovarian adenomyoma mimicking ovarian malignancy. 282548 - Dens evaginatus (tuberculated cusps): genetic and treatment considerations. 15262748 - Sparganosis presenting as a conus medullaris lesion: case report and literature review ... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Archives of pediatrics & adolescent medicine Volume: 152 ISSN: 1072-4710 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1998-11-23 Completed Date: 1998-11-23 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1100-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pharmacy Practice, College of Pharmacy, University of Illinois, Chicago 60612, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain Diseases
/
etiology*,
therapy Child, Preschool Dimercaprol / therapeutic use Edetic Acid / therapeutic use Environmental Exposure Female Humans Iron Chelating Agents / therapeutic use* Irrigation Lead / blood* Lead Poisoning / blood, therapy* Paint / poisoning Polyethylene Glycols / administration & dosage Succimer / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Iron Chelating Agents; 0/Polyethylene Glycols; 304-55-2/Succimer; 59-52-9/Dimercaprol; 60-00-4/Edetic Acid; 7439-92-1/Lead |
| Comments/Corrections | |
Comment In:
|
Arch Pediatr Adolesc Med. 1999 Nov;153(11):1202
[PMID:
10555728
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence of Gardnerella vaginalis in prepubertal males.
Next Document: Maternal birthplace, ethnicity, and low birth weight in California.