Document Detail

Aggressive B-cell lymphomas: how many categories do we need?
MedLine Citation:
PMID:  23154748     Owner:  NLM     Status:  MEDLINE    
Aggressive B-cell lymphomas are diverse group of neoplasms that arise at different stages of B-cell development and by various mechanisms of neoplastic transformation. The aggressive B-cell lymphomas include many types, subtypes and variants of diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), mantle cell lymphoma and its blastoid variant, and B lymphoblastic lymphoma. Differences in histology, cytogenetic and molecular abnormalities, as well as the relationship with the tumor microenvironment, help define characteristic signatures for these neoplasms, and in turn dictate potential therapeutic targets. Rather than survey the entire spectrum of aggressive B-cell lymphomas, this report aims to identify and characterize important clinically aggressive subtypes of DLBCL, and explore the relationship of DLBCL to BL and the gray zone between them (B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL).
Jonathan W Said
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-16
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  26 Suppl 1     ISSN:  1530-0285     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-06     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S42-56     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / pathology
Burkitt Lymphoma / classification,  genetics,  pathology
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell / classification*,  genetics,  pathology
Lymphoma, Large B-Cell, Diffuse / classification,  genetics,  pathology
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