| Aggregations of lymphoid cells in the airways of nonsmokers, smokers, and subjects with asthma. | |
| | |
MedLine Citation:
|
PMID: 14711796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Persistent airway inflammation is present in cases with asthma and in smokers with airflow obstruction. Isolated aggregations of lymphoid cells (IALC) may be sites of localized inflammatory cell activation. Their distribution and characteristics in cartilaginous airways were assessed in postmortem tissue from nonsmokers (n=10), smokers (n=9), and cases of nonfatal (n=10) and fatal asthma (n=10). IALC were present in 70-100% of cases, were more often in proximal than distal airways, and 80% were confined to the outer airway wall. IALC with area greater than 0.1 mm2 were more frequent in both asthma groups (p<0.001). Airways with IALC had increased airway dimensions and greater numbers of eosinophils and lymphomononuclear cells. Within IALC, T and B lymphocytes were segregated and comprised more than 90% of all cells. Proliferating, apoptotic, and antigen-presenting cells (Rel B+ and HLA-DR+) were less than 5%, 30-40%, and less than 1% of all cells, respectively, and were similar in each case group. Vascular structures were increased (p < 0.01) in cases of fatal asthma. These findings show that, even in nonsmoking cases and cases without asthma, IALC are common, show cellular organization, and are associated with airway wall inflammation and remodeling. It remains to be determined if IALC contribute to or result from persistent airway inflammation in asthma. |
| | |
Authors:
|
John G Elliot; Cathryn M Jensen; Slavko Mutavdzic; Jasmine P Lamb; Neil G Carroll; Alan L James |
Related Documents
:
|
19781716 - Giant inverted t waves in the emergency department: case report and review of different... 15300556 - Treatment issues in pediatric gastric adenocarcinoma. 15898526 - Giant cell arteritis of the female genital tract: report of a case and review of the li... 17083866 - Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. 9356076 - Asymptomatic aortic stenosis and unexpected death in the trauma patient. 7358956 - Restoration of elbow flexion in arthrogryposis multiplex congenita. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-01-07 |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 169 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Mar |
Date Detail:
|
Created Date: 2004-03-08 Completed Date: 2004-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 712-8 Citation Subset: AIM; IM |
Affiliation:
|
Faculty of Regional Professional Studies, Edith Cowan University, Bunbury, WA, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asthma / immunology*, pathology* Bronchi / immunology, pathology* Bronchitis / immunology, pathology Cell Aggregation / physiology Female Humans Lymphocyte Count Lymphocytes / physiology* Male Middle Aged Smoking / immunology*, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fracture risk associated with inhaled corticosteroid use in chronic obstructive pulmonary disease.
Next Document: High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung.