Document Detail


Aggregation Behavior of Pegylated Bile Acid Derivatives.
MedLine Citation:
PMID:  22925028     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bile acids are amphiphilic endogenous steroids that act as anionic surfactants in the digestive tract and aggregate in aqueous solutions. Non-ionic surfactants were synthesized by grafting oligo(ethylene glycol) chains of various lengths (pegylation) to three bile acids (lithocholic, deoxycholic, and cholic acid) using anionic polymerization. The aggregation properties of the derivatives were studied by viscosity measurements and light scattering, as well as with steady-state and time-resolved fluorescence techniques, and the aggregates were visualized by transmission electron microscopy to elucidate the effect of pegylation on the aggregation process. The fluorescence results showed a good correlation with the capacity of the bile acid derivatives to solubilize a hydrophobic drug molecule. Solubilization of ibuprofen depends on the length and the number of grafted PEG chains and solubilization efficiency increases with fewer number of PEG chains on the bile acid. The results indicate their potential for use in the design of new bile acid-based drug delivery systems.
Authors:
Frantz Le Devedec; Denis Fuentealba; Satu Strandman; Cornelia Bohne; Julian X X Zhu
Related Documents :
16841468 - Ontogenic development of the fatty acyl chain composition of the turkey (meleagris gall...
23772048 - Regulation of human class i alcohol dehydrogenases by bile acids.
16154158 - 27-hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition ...
22286218 - Five amino acids in three hla proteins explain most of the association between mhc and ...
5289388 - Absolute configuration of cecropia juvenile hormone.
21279468 - Construction, expression, and characterization of a single-chain variable fragment anti...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human papillomavirus infection and the risk of cervical cancer in Japan.
Next Document:  Factors influencing consumer adoption of USB-based Personal Health Records in Taiwan.