Document Detail


Aggregated human colostral sIgA stimulates delayed, non-complement-dependent, NBT reduction by human neutrophils.
MedLine Citation:
PMID:  2921084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibodies often alert polymorphonuclear neutrophils (PMNs) to the presence of pathogens. In a study to learn if secretory immunoglobulins can carry out this function, we observed that as little as 4 micrograms/ml of secreted human immunoglobulin A from colostrum (sIgA), in the absence of antigen, stimulated human PMNs to reduce nitroblue tetrazolium (NBT). NBT reduction was inhibited 71% by superoxide dismutase. Active complement pathways were not required since comparable activity was obtained in the presence of heat-inactivated serum. Aggregated forms of sIgA were much more stimulatory than nonaggregated dimeric sIgA. Such interaction between PMNs and sIgA could act in situ to enhance protection against infections of exposed body sites or could initiate inflammatory tissue damage.
Authors:
W W Bullock; Y Z Wang; W L Gabler; H R Creamer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation     Volume:  13     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-20     Completed Date:  1989-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-78     Citation Subset:  IM    
Affiliation:
Department of Oral Microbiology/Immunology, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Descriptor/Qualifier:
Complement Activation
Dose-Response Relationship, Immunologic
Female
Humans
Immunoglobulin A, Secretory / metabolism*
Immunoglobulin G / metabolism
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / immunology*,  metabolism
Nitroblue Tetrazolium / metabolism
Pregnancy
Chemical
Reg. No./Substance:
0/Immunoglobulin A, Secretory; 0/Immunoglobulin G; 298-83-9/Nitroblue Tetrazolium; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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