Document Detail

Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapy.
MedLine Citation:
PMID:  17645535     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Exacerbation of epilepsy may occur following initiation of therapy with antiepileptic drugs (AEDs). The aim of this study is to analyze the clinical and EEG characteristics of a group of pediatric patients with worsening of seizures and/or EEG deterioration while on oxcarbazepine (OXC).
METHODS: A retrospective analysis of a clinical database was performed to identify patients with epilepsy treated with OXC over the past 3 years. History, neurological examination, and EEG findings were reviewed to identify any who had developed exacerbation of seizures or new abnormalities on EEG.
RESULTS: Of 290 patients on OXC, we identified 12 patients with new onset seizures, all with initial normal neurological exam and normal EEG, who developed either worsening of preexisting seizures, new seizure types, and/or EEG deterioration following introduction of OXC monotherapy. EEG changes were primarily characterized by new onset of generalized epileptiform activity not reported on the initial baseline EEG. Following substitution of OXC with a broad spectrum AED, significant improvement of seizure control and improvement in the EEG was observed.
CONCLUSIONS: These findings suggest that OXC can aggravate seizures and/or worsen EEG features in children. Following initiation of therapy with OXC, monitoring of patients with follow-up EEGs may be important, especially in patients who do not show adequate response to therapy.
Martina Vendrame; Divya S Khurana; Marcos Cruz; Joseph Melvin; Ignacio Valencia; Agustin Legido; Sanjeev V Kothare
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-07-21
Journal Detail:
Title:  Epilepsia     Volume:  48     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-02     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2116-20     Citation Subset:  IM    
Department of Pediatrics, Division of Neurology, St. Christopher's Hospital for Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia, PA 19134, U.S.A.
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MeSH Terms
Acute Disease
Anticonvulsants / adverse effects*,  therapeutic use
Carbamazepine / adverse effects,  analogs & derivatives*,  therapeutic use
Cerebral Cortex / physiopathology
Child, Preschool
Electroencephalography / drug effects*,  statistics & numerical data*
Epilepsy / chemically induced,  diagnosis,  drug therapy*
Follow-Up Studies
Neurologic Examination
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; VZI5B1W380/oxcarbazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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