| Agenesis of the corpus callosum in fetuses with mild ventriculomegaly: role of MR imaging. | |
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MedLine Citation:
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PMID: 20017009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We evaluated the role of magnetic resonance (MR) imaging in the diagnosis of corpus callosum agenesis - isolated or associated with other anomalies - in fetuses with mild cerebral ventriculomegaly, as depicted at prenatal sonography. MATERIAL AND METHODS: Between January 2005 and March 2007, 33 fetuses with a mean gestational age of 28.9 weeks (range 17-37) and mild ventriculomegaly diagnosed at prenatal sonography were included in this prospective study. All fetuses underwent MR imaging according to the following protocol: half-Fourier T2-weighted images along the three orthogonal plane according to the longitudinal axis of the mother, and subsequently three orthogonal planes were acquired according to the fetal brain. Quantitative image analysis included the size of the transverse diameter of the lateral ventricles, in the axial plane, and the thickness of the adjacent cerebral cortex. Qualitative image analysis included morphology of the lateral ventricles (normal, parallel pattern colpocephaly), signal intensity changes of the fetal brain, interruption of the germinative matrix, agenesis of the corpus callosum (complete/partial) and associated malformations. Postnatal physical examination and diagnostic imaging, as well as surgery, were the standard of diagnosis. RESULTS: Mean axial diameter of the lateral ventricle was 11.6 mm (range 10-15 mm), and mean thickness of the adjacent cerebral cortex was 2.1 mm (range 1.8-3 mm); 23/33 fetuses (70%) showed normal morphology of the lateral ventricles, and 8/33 (24%) showed abnormal morphology (parallel pattern, colpocephaly). The entire corpus callosum was visualised in 20/33 fetuses (60%). In 8/33 fetuses (25%), partial agenesis was diagnosed, whereas in 5/33 (15%), there was hypogenesis. In 6/13 fetuses (46%), isolated corpus callosum agenesis was detected, and two cases of hypogenesis of the corpus callosum were misinterpreted - overestimated in one case and underestimated in another. CONCLUSIONS: MR imaging may prove to be a useful second-line imaging modality in the prenatal diagnosis of corpus callosum agenesis in fetuses with mild ventriculomegaly. |
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Authors:
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R Manfredi; A Tognolini; C Bruno; R Raffaelli; M Franchi; R Pozzi Mucelli |
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Publication Detail:
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Type: Journal Article Date: 2009-12-16 |
Journal Detail:
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Title: La Radiologia medica Volume: 115 ISSN: 1826-6983 ISO Abbreviation: Radiol Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177625 Medline TA: Radiol Med Country: Italy |
Other Details:
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Languages: eng; ita Pagination: 301-12 Citation Subset: IM |
Affiliation:
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Istituto di Radiologia, Universit? di Verona, Policlinico G.B. Rossi, P.le L.A. Scuro 10, 37134, Verona, Italy. rmanfredi@univr.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Ventricles
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abnormalities,
embryology,
ultrasonography Contrast Media Corpus Callosum / abnormalities*, embryology Female Fetal Diseases / diagnosis* Gestational Age Humans Magnetic Resonance Imaging / methods* Pregnancy Pregnancy Outcome Pregnancy, Multiple Prenatal Diagnosis* Prognosis Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
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