Document Detail


Ageing and testicular function in Octodon degus.
MedLine Citation:
PMID:  9430437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study analyses cell loss and proliferation which account for the decrease in the number of germ cell populations in the senile male Octodon degus. This is a good model to study ageing in wild animals, since it has recently been incorporated as a laboratory animal but still has a high degree of genetic heterogeneity, thus representing a situation found in natural systems. The cell loss from pachytene spermatocytes to round spermatids is estimated by cell counts in the cross section of seminiferous tubules. DNA testicular synthesis is measured by scintillation counting and the index of labelling of spermatogonia by radioautography of testes comparing sexually mature young animals and senile animals. Other determinations in both groups are testis weight, thickness of the albuginea and tubular wall, daily sperm production, percentage of depleted seminiferous tubules and nuclear cell diameters of germ cells. The results suggest a decrease in the number of cell population in the senile animals resulting from an increase in physiological cell loss coupled with a decreased proliferative spermatogonial activity. There is also a decreased yield of meiosis in terms of round spermatid production. Lowered testosterone levels both in plasma and testicular parenchymal fluid are found in senile animals. All these senescent changes reflect an altered remodelling activity of the seminiferous epithelium and presumably also of Leydig cells.
Authors:
E B Obregón; O Ramirez
Related Documents :
2690397 - The sertoli cell cytoskeleton: a target for toxicant-induced germ cell loss.
15791597 - In vivo analysis of phagocytosis of apoptotic cells by testicular sertoli cells.
12558527 - Isoforms of angiotensin i-converting enzyme in the development and differentiation of h...
17897587 - Changes in the testis seminiferous tubules and interstitium in prepubertal bull calves ...
2334817 - Nerve growth factor released into the bloodstream following intraspecific fighting indu...
19184457 - Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Andrologia     Volume:  29     ISSN:  0303-4569     ISO Abbreviation:  Andrologia     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Genetics, University of Chile Medical School, Santiago.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Epididymis / cytology
Male
Organ Size
Rodentia / physiology*
Sperm Count
Spermatogonia
Testis / cytology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Zona pellucida mediated acrosome reaction and sperm morphology.
Next Document:  Flow cytometric determination of spermatozoa binding monoclonal antibodies does not improve the pred...