Document Detail


Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes?
MedLine Citation:
PMID:  15096696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dolichol is a polyprenol compound broadly distributed in membranes, biosynthetized by the general isoprenoid pathway from acetate via mevalonate and farnesyl pyrophosphate. Dolichol lays inside the membrane between the two leaflets of the lipid bilayer very close to the tail of phospholipid fatty acids. No definite catabolic pathways for this molecule have yet been identified. Evidence is produced that dolichol levels increase dramatically with increasing age; that anti-ageing caloric restriction retards this age-associated change; that dolichol may act as a radical scavenger of peroxidized lipids belonging to the cell membranes. In view of the polyunsaturated fatty acids (PUFA), dolichol and Vitamin E location and stechiometry, it is proposed that molecules might interact each-other to form a highly matched free-radical-transfer chain, whose malfunctioning might be involved in statin toxicity and neurodegenerative diseases.
Authors:
E Bergamini; R Bizzarri; G Cavallini; B Cerbai; E Chiellini; A Donati; Z Gori; A Manfrini; I Parentini; F Signori; I Tamburini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  6     ISSN:  1387-2877     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-20     Completed Date:  2004-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM    
Affiliation:
Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Pisa, Italy. ebergami@ipg.med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Aging / drug effects*,  physiology*
Animals
Antioxidants / physiology*
Cell Membrane / metabolism
Dolichol / metabolism,  pharmacology,  physiology*
Energy Intake
Free Radical Scavengers / pharmacology
Lipid Peroxidation / drug effects
Oxidative Stress / drug effects*
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 2067-66-5/Dolichol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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