| Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation. | |
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MedLine Citation:
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PMID: 18373394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension-induced myocardial metabolic, structural and electrophysiological remodeling deteriorates with aging and contributes to both heart failure and occurrence of malignant arrhythmias. It has been shown in clinical trials that n-3 polyunsaturated fatty acids (n-3 PUFA) reduce the incidence of cardiovascular diseases and sudden cardiac death. We investigated the cardioprotective effects of n-3 PUFA in aged spontaneously hypertensive rats (SHR) and possible cellular mechanisms involved. Male and female 14-moth-old SHR were fed with n-3 PUFA (Vesteralens, Norway, 20 mg/day for two months) and compared with untreated SHR. Results showed that n-3 PUFA supplementation led to 1) significant decline of blood pressure; 2) suppression of inducible ventricular fibrillation (VF) by 57 % (male) and 67 % (female), although the arrhythmogenic substrates, like fibrosis, hypertrophy and abnormal gap junctions distribution were not eliminated; 3) preservation of the cardiomyocytes and the integrity of their junctions; 4) enhancement of energetic metabolism enzyme activity; 5) augmentation of capillary density associated with increased alkaline phosphatase and decreased dipeptidyl peptidase-4 (DPP4) activity and 6/ increase in gap junction channel connexin-43 expression. Thus, aged male as well as female SHR benefit from n-3 PUFA supplementation that results in decrease in VF susceptibility, partly due to an improvement of myocardial metabolic state, cardiomyocyte and cell-to-cell junctions integrity and Cx43 up-regulation. |
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Authors:
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M Mitasíková; S Smidová; A Macsaliová; V Knezl; K Dlugosová; L Okruhlicová; P Weismann; N Tribulová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-28 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 57 Suppl 2 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: S39-48 Citation Subset: IM |
Affiliation:
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Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Blood Pressure / drug effects Capillaries / drug effects Connexin 43 / metabolism Dietary Supplements* Disease Models, Animal Energy Metabolism / drug effects Fatty Acids, Omega-3 / pharmacology* Female Hypertension / complications, drug therapy*, metabolism, physiopathology Male Myocardium / enzymology, metabolism*, pathology Myocytes, Cardiac / drug effects, metabolism Rats Rats, Inbred SHR Tight Junctions / drug effects, metabolism Ventricular Fibrillation / etiology, metabolism, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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