Document Detail

Age variance of left ventricular diameters in dogs with cardiac disease.
MedLine Citation:
PMID:  9467419     Owner:  NLM     Status:  MEDLINE    
Ventricular size increases during growth, but often due to cardiac disease. This study aims to describe left ventricular dimension interrelations using a representation that is applicable to patients with cardiac disease, and subsequently to statistically study possible age and gender influences in a large population. In retrospect we analyzed echocardiographically obtained diameters of the left ventricle in 442 dogs of various breeds with congenital or acquired heart disease. Also, we compared our findings with published data on humans and other animals. Multivariate regression analysis was applied to assess possible influences of age and gender. A high correlation was found for end-systolic diameter (ESD) versus end-diastolic diameter (EDD): ESD (cm) = -1.01 cm + 0.93 x EDD (cm) with r = 0.94, p < .00001. Next, these patients were categorized into three age groups (divisions at 3 and 7 years). We detected a slight age dependent effect: the regression coefficients for the younger group differed from the two older groups. No significant gender-related influence was detected. The observation of a high correlation for the ESD versus EDD relationship could be confirmed by reanalysis of published data on normal individuals and human patients. The newly described relationship between ESD and EDD applies in particular to cardiac patients. This is a relevant finding, because clinically important indices of ventricular performance generally depend on ESD, EDD or both. Thus, ESD versus EDD offers a convenient framework for studies on cardiac volume regulation and performance in the cardiopathological spectrum, while permitting incorporation of modulating effects related to age.
P L Kerkhof; A Roos; G ter Haar; S Kocsis; H L Pijnenburg; A A Stokhof
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  53     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-03     Completed Date:  1998-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  B25-31     Citation Subset:  AIM; IM    
Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
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MeSH Terms
Age Factors
Aging / pathology*
Cardiac Volume
Cardiomyopathy, Dilated / pathology,  ultrasonography,  veterinary*
Dog Diseases / pathology*,  ultrasonography
Heart Defects, Congenital / pathology,  ultrasonography,  veterinary*
Heart Valve Diseases / pathology,  ultrasonography,  veterinary*
Heart Ventricles / pathology*,  ultrasonography
Multivariate Analysis
Myocardial Contraction
Regression Analysis
Retrospective Studies
Sex Factors
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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