Document Detail

Age-specific reference values for cerebrospinal fluid protein concentration in neonates and young infants.
MedLine Citation:
PMID:  20629018     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood-CSF barrier matures. However, published studies differ in the reported rate, timing, and magnitude of this decline.
OBJECTIVE: To quantify the age-related changes in CSF protein concentration and to determine accurate, age-specific reference values for neonates and young infants.
DESIGN, SETTING AND PATIENTS: This cross-sectional study included infants age 56 days or younger who had a lumbar puncture performed in the emergency department of an urban tertiary care children's hospital between January 1, 2005 and June 30, 2007. Infants with conditions associated with elevated CSF protein concentrations, including traumatic lumbar puncture and bacterial or viral meningitis, were excluded.
RESULTS: Of 1064 infants undergoing lumbar puncture, 375 (35%) met inclusion criteria. The median CSF protein value was 58 mg/dL (interquartile range: 48-72 mg/dL). In linear regression, the CSF protein concentration decreased 6.8% (95% confidence interval [CI], 5.4%-8.1%; P < 0.001) with each 1 week increase in age. The 95th percentile values were 115 mg/dL for infants ≤28 days and 89 mg/dL for infants 29-56 days. The 95th percentile values by age category were as follows: ages 0-14 days, 132 mg/dL; ages 15-28 days, 100 mg/dL; ages 29-42 days, 89 mg/dL; and ages 43-56 days, 83 mg/dL.
CONCLUSIONS: We quantify the age-related decline in CSF protein concentration among infants 56 days of age and younger and provide age-specific reference values. The values reported here represent the largest series to-date for this age group.
Samir S Shah; Jessica Ebberson; Lori A Kestenbaum; Richard L Hodinka; Joseph J Zorc
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-07-13
Journal Detail:
Title:  Journal of hospital medicine : an official publication of the Society of Hospital Medicine     Volume:  6     ISSN:  1553-5606     ISO Abbreviation:  J Hosp Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-06-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101271025     Medline TA:  J Hosp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Society of Hospital Medicine.
Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Age Factors
Cerebrospinal Fluid Proteins / cerebrospinal fluid*
Cross-Sectional Studies
Hospitals, Pediatric
Infant, Newborn
Reference Values
Grant Support
K01 AI073729-02/AI/NIAID NIH HHS; K01 AI073729-04/AI/NIAID NIH HHS; K01 AI073729-06/AI/NIAID NIH HHS; K01 AI73729/AI/NIAID NIH HHS
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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