| Age-specific onset of beta-amyloid in beagle brains. | |
| | |
MedLine Citation:
|
PMID: 8744408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
As part of an effort to characterize Alzheimer's disease-like neuropathy in the canine brain we have determined the age of onset of spontaneous beta-amyloid deposition in 103 laboratory-raised beagles. Tissue samples for each subject were obtained from hippocampal and cortical regions and examined for the incidence and density of beta-amyloid deposition after staining with modified Bielschowsky silver stain and immunohistochemistry. Amyloid deposition was characterized as diffuse plaque or cloud-like formation. The diffuse type of beta-amyloid plaque formation predominated in all brain regions examined. A threshold effect of plaque development was observed; no plaques were apparent in dogs before the age of 10 years, while 36% of dogs aged 11.1-12.9, 60% of dogs aged 13.0-15.0, and 73% of dogs aged 15.1-17.8 developed beta-amyloid deposits. Additionally, a significant increase in plaque density was observed with increasing age. |
| | |
Authors:
|
M J Russell; M Bobik; R G White; Y Hou; S A Benjamin; J W Geddes |
Related Documents
:
|
19264328 - Blood-brain barrier alterations in ageing and dementia. 10332828 - Age-related changes in the brain of the dog. 16730918 - Cytokine-induced activation of glial cells in the mouse brain is enhanced at an advance... 22062438 - State of the art in anti-aging trends. 17805078 - Prevalence of exercise-induced bronchospasm in a cohort of varsity college athletes. 22589228 - Neuropsychology and cognitive health in healthy older adults: a brief overview for psyc... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neurobiology of aging Volume: 17 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 1996 Mar-Apr |
Date Detail:
|
Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 269-73 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, University of California, Davis 95616, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age of Onset Aging / pathology Amyloid beta-Protein / metabolism* Animals Brain / pathology* Brain Chemistry / physiology Cerebral Amyloid Angiopathy / metabolism, pathology* Cerebral Cortex / metabolism, pathology Dogs Hippocampus / metabolism, pathology Immunohistochemistry |
| Grant Support | |
ID/Acronym/Agency:
|
223-92-6001//PHS HHS; AG10678/AG/NIA NIH HHS; AG11350/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Amyloid beta-Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The canine as an animal model of human aging and dementia.
Next Document: Cerebral amyloid angiopathy and plaques, and visceral amyloidosis in aged macaques.