| Age-specific impairment of morris water maze performance following neonatal exposure to magnetic resonance image in rats. | |
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MedLine Citation:
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PMID: 17311539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effects of magnetic resonance image (MRI) exposure on CNS development, we examined the effects of neonatal exposure of rats to a MRI magnetic field on their performance in the Morris water maze. After birth, all litters were randomly divided into an MRI-scanning group (experimental group) comprised of 7 mother rats and their offspring, and a control group, which consisted of the other 7 mothers and their pups. Newborn rat pups of MRI-scanning group were exposed to a 1.5 T magnetic resonance image (MRI) magnetic field for 7 days (postnatal day 1-day 7, 10 min/day). And behavioral tests were taken at 1st-, 2nd- and 5th-month after birth. At the age of 2 months postnatal, both male and female rats of the experimental groups made fewer crossings over the target area in the probe trial than did the control group. This result showed that the exposed animals represented a "reference memory" deficit, that is to say, these rats had a deficit ability to use environmental cues to locate the former position in space. No deficits were evident in the 1st- and 5th-month groups. These results demonstrate an age-specific cognitive/behavioral deficit induced by neonatal exposure to an MRI magnetic field. These findings indicate that the safety of MRI exposure must be considered with care and appropriate cautions should be taken. |
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Authors:
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Lin Yang; You-Min Guo; Tai-Zhen Han; Kai Meng; Wen Xie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current neurovascular research Volume: 4 ISSN: 1567-2026 ISO Abbreviation: - Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-21 Completed Date: 2007-04-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208439 Medline TA: Curr Neurovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, Key Laboratory of Environment and Genes Related to Diseases, School of Medicine, Xi'an Jiaotong University, Xi'an, Shannxi 710061, The People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Cognition Disorders / etiology* Female Magnetic Resonance Imaging / adverse effects* Male Maze Learning / radiation effects* Memory Disorders / etiology Pregnancy Rats Rats, Sprague-Dawley Reaction Time |
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