| Age- and size-related changes in the inner ear and hearing ability of the adult zebrafish (Danio rerio). | |
| | |
MedLine Citation:
|
PMID: 12162367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fishes, unlike most other vertebrate groups, continue to add sensory hair cells to their ears for much of their lives. However, it is not clear whether the addition ever stops or how the addition of sensory cells impacts hearing ability. In this article, we tested both questions using the zebrafish, Danio rerio. Our results not only have important implications for understanding the consequences of adding sensory receptors, but these results for normal zebrafish also serve as valuable baseline information for future studies of select mutations on the ear and hearing of this species. Our results show that hair cell production continues in uncrowded zebrafish up to 10 months of age (about one-third of a normal life span), but despite this addition there is no change in hearing sensitivity or bandwidth. Therefore, hearing is not related to the number of sensory cells in the ear in juvenile and adult animals. We also show that despite no net addition of hair cells after about 10 months, hair cells are still being produced, but at a lower rate, presumably to replace cells that are dying. Moreover, crowding of zebrafish has a marked impact on the growth of the fish and on the addition of sensory cells to the ear. We also demonstrate that fish size, not age, is a better indicator of developmental state of zebrafish. |
| | |
Authors:
|
Dennis M Higgs; Marcy J Souza; Heather R Wilkins; Joelle C Presson; Arthur N Popper |
Related Documents
:
|
17167097 - Progressive deafness and altered cochlear innervation in knock-out mice lacking prosapo... 19159517 - Induction of hair follicle regeneration in rat ear by microencapsulated human hair derm... 7487677 - Early inflammatory changes of the haemophilus influenzae-induced experimental otitis me... 7330857 - Epidermal feet in pupal segment morphogenesis. 21448157 - Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome s... 3701887 - Cellular effects of a brain extract factor or factors inhibiting neuroblastoma cell gro... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 3 ISSN: 1525-3961 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2002 Jun |
Date Detail:
|
Created Date: 2002-08-06 Completed Date: 2003-02-10 Revised Date: 2011-10-27 |
Medline Journal Info:
|
Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
|
Languages: eng Pagination: 174-84 Citation Subset: IM |
Affiliation:
|
Department of Biology, University of Maryland, College Park 20742, USA. dh201@umail.umd.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animals Body Constitution / physiology Cell Death / physiology Cell Division / physiology Crowding Hair Cells, Auditory / cytology, growth & development*, physiology* Hearing / physiology* Zebrafish |
| Grant Support | |
ID/Acronym/Agency:
|
AG015681/AG/NIA NIH HHS; DC-00046/DC/NIDCD NIH HHS; DC04502-01/DC/NIDCD NIH HHS |
| Comments/Corrections | |
Erratum In:
|
J Assoc Res Otolaryngol 2002 Jun;3(2):222 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age-related blood flow and capillary changes in the rat utricular macula: a quantitative stereologic...
Next Document: Holes in hearing.