| Age and a single day-14 beta-HCG can predict ongoing pregnancy following IVF. | |
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MedLine Citation:
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PMID: 19573299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current study was undertaken to investigate the use of beta human chorionic gonadotrophin (beta-HCG) concentration and other significant factors to predict the likelihood of an IVF pregnancy progressing to detection of cardiac activity by ultrasound, and to create data tables which can be used for patient counselling. A retrospective data analysis was undertaken of 1374 IVF cycles performed from January 1997 to July 2007, resulting in 662 pregnancies. Maternal age (P = 0.0005), day-14 (P < 0.001) and day-16 (P < 0.001) post-oocyte aspiration beta-HCG concentrations were found to be significant in predicting pregnancy outcome. Multiple logistic regression modelling revealed that the most accurate predictive model used a single day-14 beta-HCG concentration and maternal age. Day-14 and day-16 beta-HCG concentrations were highly correlated, with the addition of a day-16 concentration adding no additional predictive value. Ongoing pregnancy rates were proportional to day-14 beta-HCG concentration and inversely proportional to maternal age. The multiple pregnancy incidence increased proportionally with the initial beta-HCG concentration. Thus, for the counselling of patients following IVF, a single day-14 post-oocyte-aspiration beta-HCG concentration and maternal age are most predictive of the pregnancy continuing to detection of cardiac activity by ultrasound. |
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Authors:
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Travis W McCoy; Steven T Nakajima; Henry Cl Bohler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 19 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-03 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 114-20 Citation Subset: IM |
Affiliation:
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Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Women's Health, University of Louisville, 601 South Floyd Street, Suite 300, Louisville, KY 40202, USA. travis.mccoy@louisville.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / administration & dosage* Female Fertilization in Vitro* Heart / embryology Humans Likelihood Functions Maternal Age* Pregnancy Pregnancy Outcome Retrospective Studies Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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