Document Detail


Age, sex and source of hamster affect experimental cholesterol cholelithiasis.
MedLine Citation:
PMID:  8277829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we examined the effect of the following factors on a hamster model of cholesterol cholelithiasis: (i) the source of the golden Syrian hamsters (Sasco, Omaha, NE or Charles River, Wilmington, MA), (ii) the sex of the experimental animals and (iii) their age (4 wk vs. 8 wk of age). All hamsters were fed a semipurified diet which contained cholesterol (0.3%) and palmitic acid (1.2%). No cholesterol gallstones formed in any of the female hamsters regardless of age or source. The 4-week-old male hamsters from Sasco had the greatest incidence of gallstones (93%). The 8-week-old male hamsters tended to have a lower incidence of cholesterol gallstones than the younger ones, regardless of the commercial supplier (67 vs. 93% for Sasco and 27 vs. 40% for Charles River). Female hamsters had higher liver and serum cholesterol levels than the male hamsters; Charles River hamsters had lower serum cholesterol concentrations than the Sasco animals. Total biliary lipid concentrations were highest in Sasco male hamsters, but biliary cholesterol (mol%) was lower in the males than in the females (4.2-4.5% vs. 6.1-7.1%) regardless of age. The cholesterol saturation indices were higher in the Sasco females than the corresponding males; these values were lower in the Sasco hamsters than the Charles River animals, regardless of age or sex. The male Sasco hamsters had a higher total biliary bile acid concentration (98.9 mg/mL) than the Sasco females (58.9 mg/mL) and the Charles River animals (24.6 mg/mL for males and 38.2 mg/mL for females). The percentage of chenodeoxycholic acid in bile was significantly lower, and the percentage of cholic acid was higher in all females as compared to males.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
N Ayyad; B I Cohen; E H Mosbach; S Miki; T Mikami; Y Mikami; R J Stenger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  28     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-09     Completed Date:  1994-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  981-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, Beth Israel Medical Center, New York, New York 10003.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Laboratory
Bile Acids and Salts / analysis
Cholelithiasis / chemically induced*
Cholesterol / adverse effects
Cricetinae
Dietary Fats
Disease Models, Animal*
Female
Lipids / analysis
Male
Mesocricetus*
Palmitic Acid
Palmitic Acids / adverse effects
Sex Characteristics
Grant Support
ID/Acronym/Agency:
R01 DK-43204/DK/NIDDK NIH HHS; R37 HL-24061/HL/NHLBI NIH HHS; S07 RR-05886/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats; 0/Lipids; 0/Palmitic Acids; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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