Document Detail


Age and sex differences in perioperative myocardial infarction after cardiac surgery.
MedLine Citation:
PMID:  22499802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigate age and sex differences in acute myocardial infarction (AMI) after cardiac surgery in a prospective study of 2038 consecutive patients undergoing cardiac surgery with cardiopulmonary bypass. An age of ≥ 70 years implied changes in the type of AMI from the ST-segment elevation myocardial infarction (STEMI) to non-ST-segment elevation myocardial infarction (non-STEMI). Men were more likely than women to suffer from AMI after cardiac surgery (11.8% vs. 5.6%), as a result of the higher frequency of STEMI (6% of men vs. 1.8% of women; P < 0.001) in both age groups. A troponin-I (Tn-I) peak was significantly higher in patients ≥ 70 years old. In-hospital mortality was higher in patients ≥ 70 (7.3%) than in those < 70 years old (3.3%), because of the increased mortality observed in men with non-AMI (2.1% vs. 6.3%) and women with STEMI (0% vs. 28.6%) and non-STEMI (0% vs. 36.8%, P < 0.05). Old age was associated with a higher frequency of non-STEMI, Tn-I peak, mortality and length of stay in the intensive care unit (ICU). Regardless of age, men more often suffer from AMI (particularly STEMI). AMI in women had a notable impact on excess mortality and ICU stay observed in patients ≥ 70 years of age. Clinical and Tn-I peak differences are expected in relation to age and gender after AMI post-cardiac surgery.
Authors:
Casimiro Javierre; Antoni Ricart; Rafael Manez; Elisabet Farrero; Maria L Carrio; David Rodriguez-Castro; Herminia Torrado; Josep L Ventura
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-04-11
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  15     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-10-29     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-32     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences II, School of Medicine, University of Barcelona, IDIBELL, L'Hospitalet, Barcelona, Spain. cjavierre@ub.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Analysis of Variance
Biological Markers / blood
Cardiac Surgical Procedures / adverse effects*,  mortality
Cardiopulmonary Bypass / adverse effects
Chi-Square Distribution
Female
Hospital Mortality
Humans
Incidence
Intensive Care Units
Length of Stay
Male
Myocardial Infarction / blood,  etiology*,  mortality
Perioperative Period
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
Spain
Time Factors
Troponin I / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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