Document Detail

Age-related up-regulation of beta3-adrenergic receptor in heart-failure rats.
MedLine Citation:
PMID:  20443655     Owner:  NLM     Status:  MEDLINE    
Stimulation of beta1- and beta2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta3-AR is also expressed in the heart and that its stimulation leads to negative inotropic effects. The aim of this study was to investigate the expression of beta3-AR in age-related heart-failure rats and its relevance to left ventricular dysfunction. Aging male Wistar rats were divided into young and aging groups according to age, and each group included sham-operation and heart-failure subgroups. Left ventricular end-diastolic pressure (LVEDP) and the ratio of left ventricular weight to body weight (LV/BW) were significantly higher for the aging heart-failure versus young heart-failure and the heart-failure versus sham-operation groups (P < 0.01, respectively). However, the left ventricular end-systolic pressure (LVESP) and the maximal rate of rise or fall of left ventricular pressure were all significantly lower for the aging heart-failure versus young heart-failure and the heart-failure versus sham-operation groups (P < 0.01, respectively). beta3-AR protein levels increased significantly when heart failure worsened in aging rats. These results suggest that beta3-AR expression in age-related heart-failure rats and left ventricular function were highly correlated.
Zhe Chen; Guobin Miao; Miaobing Liu; Gang Hao; Yingying Liu; Xiangyang Fang; Zhiyong Zhang; Lingqiao Lu; Jianjun Zhang; Lin Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of receptor and signal transduction research     Volume:  30     ISSN:  1532-4281     ISO Abbreviation:  J. Recept. Signal Transduct. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509432     Medline TA:  J Recept Signal Transduct Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
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MeSH Terms
Aging / genetics*,  pathology
Body Weight / physiology
Heart Failure / genetics*,  pathology,  physiopathology,  surgery
Heart Ventricles / pathology,  physiopathology
Hemodynamics / physiology
Myocardium / pathology
Organ Size / physiology
RNA, Messenger / genetics,  metabolism
Rats, Wistar
Receptors, Adrenergic, beta-3 / genetics*,  metabolism
Time Factors
Up-Regulation / genetics*
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Adrenergic, beta-3

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