Document Detail


Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.
MedLine Citation:
PMID:  12944977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that thymic involution could be best fit with a negative exponential curve N(t)=beta(0) x exp(-beta(1)t), where t represents the age (day). This regression model was applied to C57BL/6 x DBA/2 (B x D) recombinant inbred strains of mice to identify the genetic loci influencing age-related thymic involution. There was a dramatic genetic effect of B and D alleles on thymocyte count at young age and the age-related thymic involution rate. The strongest quantitative trait loci (QTL) influencing the rate of thymic involution were mapped to mouse chromosome (Chr) 9 (D9Mit20 at 62 cM) and Chr 10 (D10Mit61 at 32 cM). The strongest QTLs influencing the initial thymocyte count were mapped to ChrX (DXMit324 at 26.5 cM) and Chr 3 (D3Mit127 at 70.3 cM). The present study suggests that the initial thymus size and the rate of thymic involution may be influenced by a relatively small number of genetic loci.
Authors:
H-C Hsu; H-G Zhang; L Li; N Yi; P-A Yang; Q Wu; J Zhou; S Sun; X Xu; X Yang; L Lu; G Van Zant; R W Williams; D B Allison; J D Mountz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes and immunity     Volume:  4     ISSN:  1466-4879     ISO Abbreviation:  Genes Immun.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-28     Completed Date:  2004-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  England    
Other Details:
Languages:  eng     Pagination:  402-10     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Chromosome Mapping
Chromosomes, Mammalian / genetics
Crosses, Genetic
Female
Genotype
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Quantitative Trait, Heritable*
Thymus Gland / cytology*
Grant Support
ID/Acronym/Agency:
CA 20408/CA/NCI NIH HHS; N01 AR 6-2224/AR/NIAMS NIH HHS; R01 AG16653/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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