| Age-related pseudocapillarization of the human liver. | |
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MedLine Citation:
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PMID: 12692849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related changes in liver function are important because they may promote susceptibility to adverse drug reactions, neurotoxicity, atherosclerosis, and other important diseases in older people. Age-related changes in the rat hepatic sinusoidal endothelium, termed pseudocapillarization, have been described recently and these may contribute to hepatic impairment. The present study has examined surgical and post-mortem specimens with immunohistochemistry and transmission electron microscopy to determine whether pseudocapillarization also occurs in older humans. The age of the subject, independent of systemic disease or hepatic pathology in surgical and post-mortem samples of human liver, was associated with increased peri-sinusoidal expression of von Willebrand's factor, collagen I, collagen IV, and staining with Masson's trichrome. Electron microscopy revealed significant age-related thickening of the sinusoidal endothelium (young 165 +/- 17 nm, middle age 222 +/- 11 nm, older 289 +/- 9 nm, p < 0.001) with loss of fenestrations (young 7.7 +/- 0.7 per 10 micro m, middle age 3.6 +/- 0.5 per 10 micro m, older 1.5 +/- 0.4 per 10 micro m, p < 0.001), and age-related deposition of basal lamina and collagen. In conclusion, ageing in humans is associated with morphological changes in the sinusoidal endothelium and space of Disse which are presumptively related to the ageing process and potentially represent an important link between the ageing process and disease susceptibility. |
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Authors:
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Allan J McLean; Victoria C Cogger; Guan C Chong; Alessandra Warren; Astrid M A Markus; Jane E Dahlstrom; David G Le Couteur |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 200 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-14 Completed Date: 2003-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 112-7 Citation Subset: IM |
Copyright Information:
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Copyright 2003 John Wiley & Sons, Ltd. |
Affiliation:
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National Ageing Research Institute and the Department of Medicine, University of Melbourne and the Royal Melbourne Hospital, Parkville, Australia. a.mclean@nari.unimelb.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Capillaries Collagen / analysis Endothelium Humans Immunohistochemistry / methods Liver / blood supply*, physiology, ultrastructure Microscopy, Electron Middle Aged |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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