Document Detail


Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships.
MedLine Citation:
PMID:  10564146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our study compared left ventricular (LV) function between senescent and young adult mice through in situ pressure-volume loop analysis. Two groups of mice (n = 9 each), 6-mo-old and 16-mo-old (senescent) mice, were anesthetized with urethan and alpha-chloralose, and their LV were instrumented with a Millar 1.4-Fr conductance micromanometer catheter for the acquisition of the pressure-volume loops. The senescent mice had a significantly decreased contractile function related to load-dependent parameters, including stroke volume index, ejection fraction, cardiac output index, stroke work index, and maximum derivative of change in systolic pressure over time. The load-independent parameters, preload recruitable stroke work and the slope (end-systolic volume elastance) of the end-systolic pressure-volume relationship, were significantly decreased in the senescent mice. Heart rate and arterial elastance were not different between the two groups; however, the ventricular-to-vascular coupling ratio (ratio of elastance of artery to end-systolic volume elastance) was increased by threefold in the senescent mice (P < 0. 001). Thus there were significant decreases in contractile function in the senescent mouse heart that appeared to be related to reduced mechanical efficiency but not related to arterial elastance.
Authors:
B Yang; D F Larson; R Watson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-20     Completed Date:  1999-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1906-13     Citation Subset:  IM; S    
Affiliation:
Arizona Prevention Center, University of Arizona, Tucson, Arizona 85724, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Blood Pressure / physiology
Blood Volume / physiology
Female
Hemodynamics
Mice
Mice, Inbred C57BL
Myocardial Contraction
Ventricular Function, Left / physiology*
Grant Support
ID/Acronym/Agency:
HL-59794-01/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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