| Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status. | |
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MedLine Citation:
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PMID: 11584027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats. |
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Authors:
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B S Baek; J W Kim; J H Lee; H J Kwon; N D Kim; H S Kang; M A Yoo; B P Yu; H Y Chung |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 56 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-03 Completed Date: 2001-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: B426-31 Citation Subset: AIM; IM |
Affiliation:
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College of Pharmacy, Pusan National University, Pusan, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / physiology* Animals Base Sequence Blotting, Western Culture Techniques Diet* Dinoprostone / metabolism* Male Models, Animal Molecular Sequence Data Polymerase Chain Reaction Prostaglandin-Endoperoxide Synthases / metabolism* RNA, Messenger / analysis Rats Rats, Wistar Reactive Oxygen Species / metabolism* Sensitivity and Specificity Telencephalon / enzymology* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Reactive Oxygen Species; 363-24-6/Dinoprostone; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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