Document Detail

Age-related effect of treatment by hydrocortisone upon the histological structure of endocrine pancreas and on the blood glucose in normal and diabetic young rats.
MedLine Citation:
PMID:  6342117     Owner:  NLM     Status:  MEDLINE    
In three different age-groups (30-, 45- and 60-day-old) of normal and streptozotocin-diabetic rats the histological aspect of the endocrine pancreas and the blood glucose content were followed under basal conditions and against the background of hydrocortisone treatment (for 5 days with daily doses of 0.250 mg/100 g b.w.). It was established that in normal rats hydrocortisone affects characteristically the structure of pancreatic islets, but not glycemia homeostasis. In diabetic animals hydrocortisone aggravates the streptozotocin induced beta-cell damages of pancreatic islets and accentuates the diabetic hyperglycemia, depending on the age of individuals.
I Madar; N Mihail
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinologie     Volume:  21     ISSN:  0253-1801     ISO Abbreviation:  Endocrinologie     Publication Date:    1983 Jan-Mar
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7509386     Medline TA:  Endocrinologie     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Glucose / biosynthesis
Diabetes Mellitus, Experimental / drug therapy*
Hydrocortisone / pharmacology*
Islets of Langerhans / anatomy & histology,  drug effects*
Reg. No./Substance:
0/Blood Glucose; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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