Document Detail


Age-related differences in the pathogenesis of calcific aortic stenosis: the potential role of resistin.
MedLine Citation:
PMID:  19162347     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Aortic stenosis (AS) is considered as an atherosclerotic related process. However, there are uncertainties whether AS in the elderly is associated with the same pathophysiological processes as in younger patients. We hypothesized that the metabolic determinants of the valvular inflammatory and calcifying processes occurring in elderly patients are different from those observed earlier in life.
METHODS: Among 114 patients operated for a severe AS, a complete plasma lipid blood profile and plasma levels of adipokines (resistin, leptin) were determined. The calcium content of the aortic valve was measured and valvular inflammation was quantified.
RESULTS: Elderly patients (>or=70 years) had significantly lower LDL-C (p=0.02), lower LDL-C associated with small size particles (LDL-C <255 A) (p=0.003), and higher HDL peak particle size than younger patients (p=0.03). In addition, elderly patients had increased plasma leptin (p=0.04) and resistin (p=0.0004) levels compared to the middle-aged group (<70 years). In the elderly patients, higher plasma resistin blood levels were associated with increased valve calcium content and inflammation.
CONCLUSION: The lipid profile of elderly patients was found less atherogenic than that of middle-aged patients. On the other hand, older patients with AS had higher plasma level of resistin which was associated with the degree of valvular calcification and inflammation. These results suggest that, beyond lipid model of atherosclerosis, age-related processes affecting resistin blood levels may also be involved in the late development of AS.
Authors:
Dania Mohty; Philippe Pibarot; Jean-Pierre Després; Amélie Cartier; Benoit Arsenault; Frédéric Picard; Patrick Mathieu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-21
Journal Detail:
Title:  International journal of cardiology     Volume:  142     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  126-32     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Laboratoire d'Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart Institute/Hôpital Laval Research Center, Department of Surgery, Laval University, Quebec, Canada.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
MOP 79342//Canadian Institutes of Health Research

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