Document Detail

Age-related differences in outcomes following childhood brain insults: an introduction and overview.
MedLine Citation:
PMID:  9448369     Owner:  NLM     Status:  MEDLINE    
Despite considerable sparing of function following some forms of early brain disease, neural plasticity is far from complete. Many children with early brain insults, including those who sustain traumatic brain injury (TBI), are susceptible to both immediate and long-term neurobehavioral impairments. To introduce this symposium, the present article reviews existing research on the effects of 3 age-related factors on outcomes: age at injury, time since injury, and age at testing. Research findings support the hypothesis that development is more adversely affected the younger the child at the time of brain insult. Although we know less about how outcomes are related to the other developmental factors, there is little evidence that sequelae resolve with age. Potential brain mechanisms responsible for age-related differences are explored and methodological problems are considered. Emphasis is placed on the importance of prospective designs, measurement of developmental change, comprehensive assessments of outcome, and evaluation of factors contributing to variability in outcomes, such as premorbid status, type of brain injury, and environmental influences. Papers in this series demonstrate the utility of these methods and shed new light on developmental processes associated with childhood brain insults.
H G Taylor; J Alden
Related Documents :
19913969 - Sex differences in the adolescent brain.
21655349 - The prevalence of blinding trachoma in northern states of sudan.
17610659 - Changes of brain activity in the neural substrates for theory of mind during childhood ...
2096239 - Enlargement of the anterior horn of the lateral ventricle in schizophrenic patients: ch...
9573399 - Effects of estrogen replacement on choline acetyltransferase and trka mrna expression i...
14985419 - Incentive-elicited brain activation in adolescents: similarities and differences from y...
25190669 - Functional capacity evaluation: performance of patients with chronic non-specific low b...
21616199 - Signaling proteins that influence energy intake may affect unintentional weight loss in...
1537689 - Seroprevalence of babesiosis in greyhounds in florida.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  3     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-67     Citation Subset:  IM    
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Age of Onset
Brain Injuries / complications*
Child Development*
Cognition Disorders / etiology*
Developmental Disabilities / etiology*
Time Factors
Grant Support
MCJ-390611//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The 48-Pictures Test: a two-alternative forced-choice recognition test for the detection of malinger...
Next Document:  Predicting recovery from head injury in young children: a prospective analysis.