Document Detail


Age-related differences in outcomes following childhood brain insults: an introduction and overview.
MedLine Citation:
PMID:  9448369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite considerable sparing of function following some forms of early brain disease, neural plasticity is far from complete. Many children with early brain insults, including those who sustain traumatic brain injury (TBI), are susceptible to both immediate and long-term neurobehavioral impairments. To introduce this symposium, the present article reviews existing research on the effects of 3 age-related factors on outcomes: age at injury, time since injury, and age at testing. Research findings support the hypothesis that development is more adversely affected the younger the child at the time of brain insult. Although we know less about how outcomes are related to the other developmental factors, there is little evidence that sequelae resolve with age. Potential brain mechanisms responsible for age-related differences are explored and methodological problems are considered. Emphasis is placed on the importance of prospective designs, measurement of developmental change, comprehensive assessments of outcome, and evaluation of factors contributing to variability in outcomes, such as premorbid status, type of brain injury, and environmental influences. Papers in this series demonstrate the utility of these methods and shed new light on developmental processes associated with childhood brain insults.
Authors:
H G Taylor; J Alden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  3     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-67     Citation Subset:  IM    
Affiliation:
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Age of Onset
Brain Injuries / complications*
Child
Child Development*
Cognition Disorders / etiology*
Developmental Disabilities / etiology*
Humans
Time Factors
Grant Support
ID/Acronym/Agency:
MCJ-390611//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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