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Age-related differences in microstructure, density and biomechanics of vertebral cancellous bone of Chinese males.
MedLine Citation:
PMID:  23035988     Owner:  NLM     Status:  Publisher    
The conventional lumbar separation was performed by removing soft tissue, subsidiary structures and leaving only the vertebral body. The vertebral body was cut into two halves along the median sagittal plane, keeping the upper and lower end plates of each half, which were subsequently used for biomechanical, morphological and density experiments. From the age of 20-29 to 30-39 years, both the horizontal trabecular thickness (Tb.Th) and vertical Tb.Th decreased; the horizontal and vertical Tb.Sp increased; the plate-like trabecular Tb.Th decreased; the apparent density and volume ratio decreased; and the elastic modulus and the ultimate stress decreased; with all changes being statistically significant (p < 0.01). Similar trends were obtained from ages 40-49 to 50-59, although the changes were not significant (p > 0.05), except for the reduction in ultimate stress (p < 0.05). With aging, the collagen cross-linking capacity declined; the thicknesses of the collagen fibrils were variable, ranging from almost the same to loose, sparse or disordered thickness; and the finer collagen fibrils between the thick filaments were disorganized. In males aged from 20 to 59 years old, the horizontal and vertical Tb.Th and the plate-like Tb.Th of the vertebral body decreased, while the horizontal and vertical Tb.Sp increased. Additionally, the density, elastic modulus and the ultimate stress of the cancellous bone decreased with age. Thus, the associated changes of bone microstructure, density and biomechanics with age may lead to an increased risk of osteoporosis and fracture.
Guo-Min Liu; Chuan-Jie Xu; Ning Kong; Xiao-Min Zhu; Xing-Yi Zhang; Yan Yao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  The aging male : the official journal of the International Society for the Study of the Aging Male     Volume:  -     ISSN:  1473-0790     ISO Abbreviation:  Aging Male     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808210     Medline TA:  Aging Male     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Orthopedics & Department of Pathology, The Second Hospital of Jilin University , Changchun , China.
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