Document Detail

Age-related differences in enhancement and suppression of neural activity underlying selective attention in matched young and old adults.
MedLine Citation:
PMID:  23313874     Owner:  NLM     Status:  MEDLINE    
Selective attention reflects the top-down control of sensory processing that is mediated by enhancement or inhibition of neural activity. ERPs were used to investigate age-related differences in neural activity in an experiment examining selective attention to color under Attend and Ignore conditions, as well as under a Neutral condition in which color was task-irrelevant. We sought to determine whether differences in neural activity between old and young adult subjects were due to differences in age rather than executive capacity. Old subjects were matched to two groups of young subjects on the basis of neuropsychological test performance: one using age-appropriate norms and the other using test scores not adjusted for age. We found that old and young subject groups did not differ in the overall modulation of selective attention between Attend and Ignore conditions, as indexed by the size of the anterior Selection Positivity. However, in contrast to either young adult group, old subjects did not exhibit reduced neural activity under the Ignore relative to Neutral condition, but showed enhanced activity under the Attend condition. The onset and peak of the Selection Positivity occurred later for old than young subjects. In summary, older adults execute selective attention less efficiently than matched younger subjects, with slowed processing and failed suppression under Ignore. Increased enhancement under Attend may serve as a compensatory mechanism.
A E Haring; T Y Zhuravleva; B R Alperin; D M Rentz; P J Holcomb; K R Daffner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  Brain research     Volume:  1499     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-08-01     Revised Date:  2014-03-10    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  69-79     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Age Factors
Attention / physiology*
Brain / physiology*
Evoked Potentials / physiology*,  radiation effects*
Photic Stimulation
Reaction Time / physiology
Signal Processing, Computer-Assisted
Young Adult
Grant Support
R01 AG017935/AG/NIA NIH HHS; R01AGO17935//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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