Document Detail

Age-related degeneracy of T cell repertoire: influence of the aged environment on T cell allorecognition.
MedLine Citation:
PMID:  2384228     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to understand the mechanism of alteration of the alloreactivity of T cells in aged mice. The experiment utilized bone marrow chimeras revealed that the age-associated changes in alloreactivity are not primarily determined by the bone marrow stem cells but determined by the environment where stem cells differentiate into mature T cells. The limiting dilution analysis and microfluorometry analysis indicated that the changes lie in both frequency of alloreactive T cells and the expression of T cell antigen receptor. Such quantitative and qualitative changes seems to be the causes for declined alloreactivity of T cells in aged mice.
Y Asano; T Komuro; M Kubo; K Sano; T Tada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gerontology     Volume:  36 Suppl 1     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Department of Immunology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Age Factors
Aging / immunology*
Cell Differentiation / immunology,  physiology
Immune System / immunology,  physiology
Major Histocompatibility Complex / immunology*
Mice, Inbred BALB C
Mice, Inbred C57BL
T-Lymphocytes / immunology*
Thymus Gland / immunology,  physiology

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