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Age-related changes of skin blood flow during postocclusive reactive hyperemia in human.
MedLine Citation:
PMID:  22671957     Owner:  NLM     Status:  Publisher    
BACKGROUND/PURPOSE: The objective was to study age-related alterations in the time-amplitude characteristics of the oscillatory components of peripheral blood flow in healthy humans during postocclusive reactive hyperemia. METHODS: Forearm blood skin perfusion was studied by the method of laser Doppler flowmetry in 120 healthy volunteers, who were divided into two age groups: young (19-30 years old; n = 82) and middle-age (30-60 years old; n = 38). The forearm occlusion approach was used to reveal the reaction of the microvascular bed to transient ischemia. To estimate the age-related changes of separate oscillatory components of LDF signals during postocclusive reactive hyperemia, we applied adaptive time-amplitude wavelet analysis. RESULTS: A statistically significant increase in the skin blood perfusion after occlusion removal was revealed: 4-fold in the 1st and 3.5-fold in the 2nd group respectively. Both the amplitude of blood flow oscillations at rest and the postocclusive growth of the amplitude showed an age-related decline in the frequency intervals associated with the myogenic (0.052-0.145 Hz), sympathetic (0.021-0.052 Hz) and endothelial (0.0095-0.021 Hz) activity. CONCLUSION: The time-amplitude characteristics of the oscillatory components of peripheral blood flow depend on age, with the dependence becoming more evident after a transient ischemia.
Irina V Tikhonova; Arina V Tankanag; Nikolay K Chemeris
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)     Volume:  -     ISSN:  1600-0846     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504453     Medline TA:  Skin Res Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Institute of Cell Biophysics, Russian Academy of Sciences, Institutskaya st. 3, Pushchino, Moscow Region, 142290, Russia.
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